Immunotherapy for pediatric brain tumors: past and present

被引：31
|
作者：
Foster, Jessica B. [1 ,2 ]
Madsen, Peter J. [3 ]
Hegde, Meenakshi [4 ,5 ]
Ahmed, Nabil [4 ,5 ]
Cole, Kristina A. [1 ,2 ]
Maris, John M. [1 ,6 ]
Resnick, Adam C. [3 ,7 ]
Storm, Phillip B. [3 ,7 ]
Waanders, Angela J. [8 ]
机构：
[1] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
[2] Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Div Neurosurg, Philadelphia, PA 19104 USA
[4] Texas Childrens Hosp, Texas Childrens Canc Ctr, Houston, TX 77030 USA
[5] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[6] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
[7] Childrens Hosp Philadelphia, Ctr Data Driven Discovery Biomed, Philadelphia, PA 19104 USA
[8] Ann & Robert H Lurie Childrens Hosp Chicago, Div Oncol, Chicago, IL 60611 USA
来源：
NEURO-ONCOLOGY | 2019年 / 21卷 / 10期
关键词：
brain tumor; immunotherapy; pediatric; ACTIVATED KILLER-CELLS; WT1 PEPTIDE VACCINATION; MALIGNANT PRIMARY BRAIN; T-CELLS; ADOPTIVE IMMUNOTHERAPY; ANTIGEN PEPTIDES; HEMATOLOGICAL MALIGNANCIES; IMMUNE-RESPONSES; YOUNG-ADULTS; GLIOBLASTOMA;
D O I：
10.1093/neuonc/noz077
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The field of cancer immunotherapy has progressed at an accelerated rate over the past decade. Pediatric brain tumors thus far have presented a formidable challenge for immunotherapy development, given their typically low mutational burden, location behind the blood-brain barrier in a unique tumor microenvironment, and intratumoral heterogeneity. Despite these challenges, recent developments in the field have resulted in exciting preclinical evidence for various immunotherapies and multiple clinical trials. This work reviews the history and advances in active immunotherapy, checkpoint blockade, and adoptive T-cell therapy for pediatric brain tumors, including ongoing clinical trials.
引用
收藏
页码：1226 / 1238
页数：13
相关论文
共 50 条
  • [1] Immunotherapy Approaches for Pediatric CNS Tumors and Associated Neurotoxicity
    Finch, Elizabeth A.
    Duke, Elizabeth
    Hwang, Eugene, I
    Packer, Roger J.
    PEDIATRIC NEUROLOGY, 2020, 107 : 7 - 15
  • [2] Immunotherapy in brain tumors
    De Carli, Emilie
    Delion, Matthieu
    Rousseau, Audrey
    ANNALES DE PATHOLOGIE, 2017, 37 (01) : 117 - 126
  • [3] Immunotherapy for the treatment of pediatric brain tumors: a narrative review
    Shalita, Chidyaonga
    Hanzlik, Emily
    Kaplan, Samantha
    Thompson, Eric M.
    TRANSLATIONAL PEDIATRICS, 2022, 11 (12) : 2040 - +
  • [4] Towards Immunotherapy for Pediatric Brain Tumors
    Wang, Stacie Shiqi
    Bandopadhayay, Pratiti
    Jenkins, Misty Rayna
    TRENDS IN IMMUNOLOGY, 2019, 40 (08) : 748 - 761
  • [5] The past, present, and future of immunotherapy for bladder tumors
    Schneider, Theresa
    Zhao, Lei
    Zhu, Ziwen
    Gabrielyan, Gagik
    Xiao, Huaping
    Fajardo, Emerson D.
    Bai, Qian
    Wakefield, Mark R.
    Fang, Yujiang
    MEDICAL ONCOLOGY, 2022, 39 (12)
  • [6] Immunotherapy for Pediatric Brain Tumors
    Sayour, Elias J.
    Mitchell, Duane A.
    BRAIN SCIENCES, 2017, 7 (10):
  • [7] The past, present, and future of immunotherapy for bladder tumors
    Theresa Schneider
    Lei Zhao
    Ziwen Zhu
    Gagik Gabrielyan
    Huaping Xiao
    Emerson D. Fajardo
    Qian Bai
    Mark R. Wakefield
    Yujiang Fang
    Medical Oncology, 39
  • [8] Carbon Dots in Treatment of Pediatric Brain Tumors: Past, Present, and Future Directions
    Vallejo, Frederic A.
    Sigdel, Ganesh
    Veliz, Eduardo A.
    Leblanc, Roger M.
    Vanni, Steven
    Graham, Regina M.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (11)
  • [9] Transcriptomic observations of intra and extracellular immunotherapy targets for pediatric brain tumors
    Frederico, Stephen C.
    Raphael, Itay
    Nisnboym, Michal
    Huq, Sakibul
    Schlegel, Brent T.
    Sneiderman, Chaim T.
    Jackson, Sydney A.
    Jain, Anya
    Olin, Michael R.
    Rood, Brian R.
    Pollack, Ian F.
    Hwang, Eugene I.
    Rajasundaram, Dhivyaa
    Kohanbash, Gary
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2024, 20 (11) : 1411 - 1420
  • [10] Update on Pediatric Brain Tumors: the Molecular Era and Neuro-immunologic Beginnings
    Duke, Elizabeth S.
    Packer, Roger J.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2020, 20 (08)
12345