Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models

被引：37
作者：
Dressing, Gwen E. [1 ]
Hagan, Christy R. [1 ]
Knutson, Todd P. [1 ]
Daniel, Andrea R. [1 ]
Lange, Carol A. [1 ]
机构：
[1] Univ Minnesota, Mason Canc Ctr, Dept Med & Pharmacol, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA
来源：
ENDOCRINE-RELATED CANCER | 2009年 / 16卷 / 02期
基金：
美国国家卫生研究院;
关键词：
GROWTH-FACTOR RECEPTOR; STEROID-HORMONE RECEPTORS; HUMAN ESTROGEN-RECEPTOR; CYCLIN D1; ANDROGEN RECEPTOR; GENE-EXPRESSION; CROSS-TALK; TRANSCRIPTIONAL ACTIVATION; DOWN-REGULATION; CO-REPRESSOR;
D O I：
10.1677/ERC-08-0281
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Progesterone receptors (PR), members of the nuclear receptor superfamily, function as ligand-activated transcription factors and initiators of c-Src kinase and mitogen-activated protein kinase signaling. Bidirectional cross-talk between PR and mitogenic protein kinases results in changes in PR post-translational modification, leading to alterations in PR transcriptional activity and promoter selectivity. PR-induced rapid activation of cytoplasmic protein kinases insures precise regulatory input to downstream cellular processes that are dependent upon nuclear PR, such as cell-cycle progression, and pro-survival signaling. Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell-line models
引用
收藏
页码：351 / 361
页数：11
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