An Efficient One-Pot Synthesis of Some New 2,4-Diaryl Pyrido[3,2-c]coumarins as Potent Antimicrobial Agents

被引：35

作者：

Dawane, Bhaskar S. ^{[1
]}

Konda, Shankaraiah G. ^{[1
]}

Bodade, Ragini G. ^{[2
]}

Bhosale, Raghunath B. ^{[3
]}

机构：

[1] Yeshwant Mahavidyalaya, Dept Chem, Organ Res Lab, Nanded 431602, Maharashtra, India

[2] Swami Ramanand Teerth Marathwada Univ, Sch Life Sci, Nanded 431606, Maharashtra, India

[3] Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 01期

关键词：

POLY(ETHYLENE GLYCOL) PEG; ASYMMETRIC DIHYDROXYLATION; POLYETHYLENE-GLYCOL; ORGANIC-SYNTHESIS; SOLVENT; SYSTEM; DERIVATIVES; OLEFINS;

D O I：

10.1002/jhet.234

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Poly(ethylene glycol) (PEG-400) has been used as sustainable, nonvolatile, and environmental friendly reaction solvent for the synthesis of title compounds. Various diaryl pyrido[3,2-c]coumarins have been synthesized in one step by reacting 4-hydroxy-7-methyl-coumarin with alpha,beta-unsaturated ketones in the presence of ammonium acetate. Further, in vitro antimicrobial (antibacterial and antifungal) activities of the compounds were screened against different pathogens. The results revealed that most of them showed potent activity.

引用

页码：237 / 241

页数：5

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