Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility

被引：9
作者：
Sun, Peng [1 ]
Liu, Da-Gang [2 ]
Ye, Xiang-Ming [1 ]
机构：
[1] Hangzhou Med Coll, Rehabil & Sports Med Res Inst Zhejiang Prov, Zhejiang Prov Peoples Hosp, Peoples Hosp, Hangzhou, Peoples R China
[2] Weihai Cent Hosp, Dept Neurosurg Med, Weihai, Peoples R China
来源：
FRONTIERS IN NEUROLOGY | 2021年 / 12卷
关键词：
cholinergic receptors; α 7 nicotinic acetylcholine receptors; epilepsy; seizure susceptibility; CA1 pyramidal neuron; SYNAPTIC-TRANSMISSION; ALZHEIMERS-DISEASE; INTERNEURONS; EXCITABILITY; HIPPOCAMPUS; MODULATION; THRESHOLD; NEURONS; SYSTEM;
D O I：
10.3389/fneur.2021.656752
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A large body of data has confirmed that alpha 7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of alpha 7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of alpha 7 nAChRs. Moreover, the expression of alpha 7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that alpha 7 nAChR is an essential regulator of seizure susceptibility.
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页数：8
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