Cytotoxic Polyacetylenes from a Formosan Marine Sponge Callyspongia sp.

被引：4

作者：

Chiu, Ching-Wen ^{[1
,2
]}

Su, Huey-Jen ^{[3
]}

Lu, Mei-Chin ^{[4
,5
]}

Wang, Wei-Hsien ^{[1
,2
]}

Sheu, Jyh-Horng ^{[1
,2
,6
,7
]}

Su, Jui-Hsin ^{[1
,2
,4
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Meiho Univ, Dept Nursing, Pingtung 912, Taiwan

[4] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[5] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[6] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[7] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2014年 / 87卷 / 11期

关键词：

TUMOR-CELL-LINES; HIPPOSPONGIA SP; SESTERTERPENOIDS; ASSAY;

D O I：

10.1246/bcsj.20140188

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new polyacetylenic compounds, callysponynes A (1) and B (2), were isolated from the marine sponge Callyspongia sp. The structures of the new metabolites were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Moreover, the absolute configuration of 1 was determined by Mosher's method. Compounds 1 and 2 exhibited cytotoxic activity in vitro against MOLT-4, K-562, and HCT 116 cancer cell lines.

引用

页码：1231 / 1234

页数：4

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