Changes in lipid composition in hippocampus early and late after status epilepticus induced by kainic acid in wistar rats

被引：7

作者：

Dal-Pizzol, Felipe

Quevedo, Joao

Streck, Emilio

Walz, Roger

Moreira, Jose Claudio F.

机构：

[1] UNESP, Programa Posgrad Ciencias Saude, Lab Fisiopatol Expt, BR-88006000 Circiuma, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Clin Med, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Fed Rio Grande do Sul, Ctr Estudos Estresse Oxidat, Dept Bioquim, BR-90046900 Porto Alegre, RS, Brazil

来源：

METABOLIC BRAIN DISEASE | 2007年 / 22卷 / 01期

关键词：

oxidative stress; kainic acid; seizures; lipid peroxidation; lipid composition; membrane fluidity; INDUCED LIMBIC SEIZURES; MEMBRANE FLUIDITY; OXIDATIVE STRESS; BRAIN; PEROXIDATION; STOBADINE; RADICALS;

D O I：

10.1007/s11011-006-9033-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oxidative damage to biological membranes has been reported as a cause of alterations in many different diseases. We had previously reported lipid peroxidation in the kainic acid model of temporal epilepsy. In this study we evaluated earlier and later modifications in the lipid composition after status epileticus induced by kainic acid. Lipid composition was determined by thin-layer chromatography, in the cortex and hippocampus 12-14 h, 7-8, 75-80, or 140-150 days after the end of status epileticus. In the hippocampus there was a significant change in the lipid protein ratio after status epileticus and this was accompanied by an alteration in lipid composition in all tested times. These results suggested that lipid peroxidation induced by kainic acid could be accompanied by chronic changes in the lipid composition that could be related to the development of seizures.

引用

页码：25 / 29

页数：5

共 20 条

[11] Membrane ion transport systems during oxidative stress in rodent brain:: Protective effect of stobadine and other antioxidants
Lehotsky, J
Kaplán, P
Racay, P
Matejovicová, M
Drgová, A
Mézesová, V
[J]. LIFE SCIENCES, 1999, 65 (18-19) : 1951 - 1958
[12] KAINIC ACID-INDUCED LIMBIC SEIZURES - ELECTROPHYSIOLOGIC STUDIES
LOTHMAN, EW
COLLINS, RC
FERRENDELLI, JA
[J]. NEUROLOGY, 1981, 31 (07) : 806 - 812
[13] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[14] Altered mitochondrial membrane fluidity in AD brain
Mecocci, P
Cherubini, A
Beal, MF
Cecchetti, R
Chionne, F
Polidori, MC
Romano, G
Senin, U
[J]. NEUROSCIENCE LETTERS, 1996, 207 (02) : 129 - 132
[15] Shulz JN, 1995, J NEUROCHEM, V64, P2239, DOI 10.1046/j.1471-4159.1995.64052239.x
[16] Solans R, 2000, ARTHRITIS RHEUM-US, V43, P894, DOI 10.1002/1529-0131(200004)43:4<894::AID-ANR22>3.0.CO
[17] 2-4
[18] Erythrocyte glutathione balance and membrane stability during preeclampsia
Spickett, CM
Reglinski, J
Smith, WE
Wilson, R
Walker, JJ
McKillop, J
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1998, 24 (06) : 1049 - 1055
[19] Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats
Ueda, Y
Yokoyama, H
Niwa, R
Konaka, R
OhyaNishiguchi, H
Kamada, H
[J]. EPILEPSY RESEARCH, 1997, 26 (02) : 329 - 333
[20] Increased sensitivity to seizures in mice lacking cellular prion protein
Walz, R
Amaral, OB
Rockenbach, IC
Roesler, R
Izquierdo, I
Cavalheiro, EA
Martins, VR
Brentani, RR
[J]. EPILEPSIA, 1999, 40 (12) : 1679 - 1682

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