Oleanolic acid, a bioactive component of the leaves of Ocimum gratissimum (Lamiaceae)

被引：20

作者：

Njoku, CJ

Zeng, L

Asuzu, IU

Oberlies, NH

McLaughlin, JL

机构：

[1] Univ Nigeria, Dept Vet Physiol & Pharmacol, Nsukka, Nigeria

[2] Purdue Univ, Dept Med Chem & Mol Pharmacol, Sch Pharm & Pharmacal Sci, W Lafayette, IN 47907 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1997年 / 35卷 / 02期

关键词：

Aedes aegypti; brine shrimp test; Caenorhabditis elegans; cytotoxicity; Ocimum gratissimum; oleanolic acid; yellow fever mosquito;

D O I：

10.1076/phbi.35.2.134.13290

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-guided fractionation of the leaves of Ocimum gratissimum L. (Lamiaceae), using the brine shrimp lethality test led to the isolation of oleanolic acid Oleanolic acid showed bioactivity against a panel of six human solid tumor cell lines, the nematode Caenorhabditis elegans and yellow fever mosquito larvae Aedes aegypti. Details of the isolation and bioactivities are described.

引用

页码：134 / 137

页数：4

共 15 条

[1] IN-VIVO USE OF EXTRACTS FROM OCIMUM-GRATISSIMUM AND CYMBOPOGON-CITRATUS AGAINST PHYTOPHTHORA-PALMIVORA CAUSING BLACKPOD DISEASE OF COCOA [J].