Leucocyte and eosinophil counts predict progression-free survival in relapsed or refractory classical Hodgkin Lymphoma patients treated with PD1 inhibition

被引：28

作者：

Hude, Ida ^{[1
,2
]}

Sasse, Stephanie ^{[1
]}

Broeckelmann, Paul J. ^{[1
]}

von Tresckow, Bastian ^{[1
]}

Momotow, Jesko ^{[1
]}

Engert, Andreas ^{[1
]}

Borchmann, Sven ^{[1
]}

机构：

[1] Univ Hosp Cologne, GHSG, Dept Internal Med 1, Cologne, Germany

[2] Univ Hosp Ctr Zagreb, Div Haematol, Dept Internal Med, Zagreb, Croatia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2018年 / 181卷 / 06期

关键词：

Hodgkin lymphoma; immune checkpoint inhibition; biomarkers; eosinophils; immunotherapy; BRENTUXIMAB VEDOTIN; NIVOLUMAB; BLOCKADE; FAILURE;

D O I：

10.1111/bjh.14705

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：837 / 840

页数：4

共 10 条

[1] The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape [J].

Aldinucci, Donatella ;

Gloghini, Annunziata ;

Pinto, Antonio ;

De Filippi, Rosaria ;

Carbone, Antonino .

JOURNAL OF PATHOLOGY, 2010, 221 (03) :248-263

[2] PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma [J].

Ansell, Stephen M. ;

Lesokhin, Alexander M. ;

Borrello, Ivan ;

Halwani, Ahmad ;

Scott, Emma C. ;

Gutierrez, Martin ;

Schuster, Stephen J. ;

Millenson, Michael M. ;

Cattry, Deepika ;

Freeman, Gordon J. ;

Rodig, Scott J. ;

Chapuy, Bjoern ;

Ligon, Azra H. ;

Zhu, Lili ;

Grosso, Joseph F. ;

Kim, Su Young ;

Timmerman, John M. ;

Shipp, Margaret A. ;

Armand, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (04) :311-319

[3] Programmed Death-1 Blockade With Pembrolizumab in Patients With Classical Hodgkin Lymphoma After Brentuximab Vedotin Failure [J].

Armand, Philippe ;

Shipp, Margaret A. ;

Ribrag, Vincent ;

Michot, Jean-Marie ;

Zinzani, Pier Luigi ;

Kuruvilla, John ;

Snyder, Ellen S. ;

Ricart, Alejandro D. ;

Balakumaran, Arun ;

Rose, Shelonitda ;

Moskowitz, Craig H. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (31) :3733-+

[4] Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells [J].

Carretero, Rafael ;

Sektioglu, Ibrahim M. ;

Garbi, Natalio ;

Salgado, Oscar C. ;

Beckhove, Philipp ;

Haemmerling, Guenter J. .

NATURE IMMUNOLOGY, 2015, 16 (06) :609-+

[5] Revised response criteria for malignant lymphoma [J].

Cheson, Bruce D. ;

Pfistner, Beate ;

Juweid, Malik E. ;

Gascoyne, Randy D. ;

Specht, Lena ;

Horning, Sandra J. ;

Coiffier, Bertrand ;

Fisher, Richard I. ;

Hagenbeek, Anton ;

Zucca, Emanuele ;

Rosen, Steven T. ;

Stroobants, Sigrid ;

Lister, T. Andrew ;

Hoppe, Richard T. ;

Dreyling, Martin ;

Tobinai, Kensei ;

Vose, Julie M. ;

Connors, Joseph M. ;

Federico, Massimo ;

Diehl, Volker .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :579-586

[6] Involvement of eosinophils in the anti-tumor response [J].

Gatault, Solene ;

Legrand, Fanny ;

Delbeke, Marie ;

Loiseau, Sylvie ;

Capron, Monique .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (09) :1527-1534

[7] A prognostic score for advanced Hodgkin's disease [J].

Hasenclever, D ;

Diehl, V .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (21) :1506-1514

[8] Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab [J].

Martens, Alexander ;

Wistuba-Hamprecht, Kilian ;

Foppen, Marnix Geukes ;

Yuan, Jianda ;

Postow, Michael A. ;

Wong, Phillip ;

Romano, Emanuela ;

Khammari, Amir ;

Dreno, Brigitte ;

Capone, Mariaelena ;

Ascierto, Paolo A. ;

Di Giacomo, Anna Maria ;

Maio, Michele ;

Schilling, Bastian ;

Sucker, Antje ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Eigentler, Thomas K. ;

Martus, Peter ;

Wolchok, Jedd D. ;

Blank, Christian ;

Pawelec, Graham ;

Garbe, Claus ;

Weide, Benjamin .

CLINICAL CANCER RESEARCH, 2016, 22 (12) :2908-2918

[9] Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab [J].

Weide, Benjamin ;

Martens, Alexander ;

Hassel, Jessica C. ;

Berking, Carola ;

Postow, Michael A. ;

Bisschop, Kees ;

Simeone, Ester ;

Mangana, Johanna ;

Schilling, Bastian ;

Di Giacomo, Anna Maria ;

Brenner, Nicole ;

Kaehler, Katharina ;

Heinzerling, Lucie ;

Gutzmer, Ralf ;

Bender, Armin ;

Gebhardt, Christoffer ;

Romano, Emanuela ;

Meier, Friedegund ;

Martus, Peter ;

Maio, Michele ;

Blank, Christian ;

Schadendorf, Dirk ;

Dummer, Reinhard ;

Ascierto, Paolo A. ;

Hospers, Geke ;

Garbe, Claus ;

Wolchok, Jedd D. .

CLINICAL CANCER RESEARCH, 2016, 22 (22) :5487-5496

[10] Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial [J].

Younes, Anas ;

Santoro, Armando ;

Shipp, Margaret ;

Zinzani, Pier Luigi ;

Timmerman, John M. ;

Ansell, Stephen ;

Armand, Philippe ;

Fanale, Michelle ;

Ratanatharathorn, Voravit ;

Kuruvilla, John ;

Cohen, Jonathon B. ;

Collins, Graham ;

Savage, Kerry J. ;

Trneny, Marek ;

Kato, Kazunobu ;

Farsaci, Benedetto ;

Parker, Susan M. ;

Rodig, Scott ;

Roemer, Margaretha G. M. ;

Ligon, Azra H. ;

Engert, Andreas .

LANCET ONCOLOGY, 2016, 17 (09) :1283-1294

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