Synthesis and in vitro study of [1,3,4]thiadiazol-2yl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles as antimicrobial agents

被引：11

作者：

Seelam, Nareshvarma ^{[1
]}

Shrivastava, S. P. ^{[1
]}

机构：

[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Chem, Heterocycl Res Lab, Sagar 470003, MP, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2016年 / 20卷 / 01期

关键词：

Thiadiazole; Pyrazole; Thiazolidinones; Antimicrobial studies; Anti-tuberculosis studies; ANTIPROLIFERATIVE ACTIVITY; ANTITUBERCULOSIS ACTIVITY; ANTIBACTERIAL ACTIVITY; 1,3,4-THIADIAZOLE; DERIVATIVES; ANTIFUNGAL;

D O I：

10.1016/j.jscs.2012.07.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of 3,5-diphenyl-6-(5-p-tolyl-1,3,4 thiadiazol-2y1)-3,3a,5,6 tetrahydro-2H pyrazolo3,4-dthiazole 6ag were synthesized by the reaction of chalcone derivatives of 1,3,4 thiadiazol-2-yl)-thiazolidin-4-one 5a g with hydrazine hydrate. The chemical structures of these compounds were confirmed by IR, NMR (H-1 & C-13) and mass spectral studies. Synthesized compounds 6a g were evaluated for their antimicrobial and anti-tubercular activities. Some of the compounds exhibited well antimicrobial and anti-tubercular activities compared to the standard drugs. (C) 2012 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：33 / 39

页数：7

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