Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor

被引：9

作者：

Kayashima, Tomoko ^{[1
]}

Mori, Masaharu ^{[2
]}

Mizutani, Ryo ^{[3
]}

Nishio, Kazuyuki ^{[3
]}

Kuramochi, Kouji ^{[3
]}

Tsubaki, Kazunori ^{[3
]}

Yoshida, Hiromi ^{[4
,5
]}

Mizushina, Yoshiyuki ^{[4
,5
]}

Matsubara, Kiminori ^{[1
,4
]}

机构：

[1] Hiroshima Univ, Dept Human Life Sci Educ, Grad Sch Educ, Hiroshima 7398524, Japan

[2] Okayama Prefectural Univ, Dept Nursing, Fac Hlth & Welf Sci, Okayama 7191197, Japan

[3] Kyoto Prefectural Univ, Grad Sch Life & Environm Sci, Sakyou Ku, Kyoto 6068522, Japan

[4] Kobe Gakuin Univ, Cooperat Res Ctr Life Sci, Chuo Ku, Kobe, Hyogo 6518586, Japan

[5] Kobe Gakuin Univ, Lab Food & Nutr Sci, Dept Nutr Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 17期

关键词：

Vitamin K; 1,4-Naphthoquinone; Angiogenesis; Endothelial cells; Aortic rings; IN-VITRO; DNA-POLYMERASE; ANTIANGIOGENIC ACTIVITY; ENDOTHELIAL-CELLS; CAPILLARY GROWTH; POTENT INHIBITOR; COLLAGEN GEL; FATTY-ACID; CANCER; VIVO;

D O I：

10.1016/j.bmc.2010.07.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten vitamin K(3) derivatives were synthesized and screened for anti-angiogenic activity. Results indicated that amine derivatives (1a-d) exerted a stronger inhibition effect on angiogenesis compared to alkyl derivatives (2a-d). In addition to being the most potent inhibitor, 1b also suppressed human umbilical vein endothelial cell tube formation and proliferation. These results suggest that vitamin K3 amine derivatives with shorter alkyl chains, such as 1b, could be useful for developing anti-angiogenic agents. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6305 / 6309

页数：5

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