Sleep and neurological autoimmune diseases

被引:48
作者
Iranzo, Alex [1 ,2 ]
机构
[1] Hosp Clin Barcelona, Neurol Serv, Sleep Ctr, Barcelona, Spain
[2] CIBERNED, IDIBAPS, Barcelona, Spain
关键词
RAPID-EYE-MOVEMENT; PROGRESSIVE SUPRANUCLEAR PALSY; NMDA-RECEPTOR ENCEPHALITIS; GUILLAIN-BARRE-SYNDROME; BEHAVIOR DISORDER; REM-SLEEP; LIMBIC ENCEPHALITIS; IGLON5; AUTOIMMUNITY; STEM ENCEPHALITIS; AGRYPNIA EXCITATA;
D O I
10.1038/s41386-019-0463-z
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients experiment a number of neurological manifestations that may include insomnia, excessive daytime sleepiness, cataplexy, central hypoventilation, and REM sleep behavior disorder. Polysomnographic evaluation may reveal disorganized sleep architecture involving both NREM and REM sleep, and REM sleep intrusions into wakefulness. The study of sleep disorders in the setting of autoimmune diseases (e.g., narcolepsy, anti-IgLON5 disease, paraneoplastic neurological syndromes) shows that an abnormal immune-mediated (humoral or cellular) response target the neuronal structures (e.g., brainstem, hypothalamus) and neurotransmitters systems (e.g., hypocretin) that regulate sleep resulting in sleep impairment. It is a window to examine the link between the autoimmune system and the sleep regulation at the molecular, cellular, and anatomic level.
引用
收藏
页码:129 / 140
页数:12
相关论文
共 99 条
[1]   New developments in the management of narcolepsy [J].
Abad, Vivien C. ;
Guilleminault, Christian .
NATURE AND SCIENCE OF SLEEP, 2017, 9 :39-57
[2]   Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma [J].
Adams, Chris ;
McKeon, Andrew ;
Silber, Michael H. ;
Kumar, Rajeev .
ARCHIVES OF NEUROLOGY, 2011, 68 (04) :521-524
[3]  
American Academy of Sleep Medicine, 2014, Internet AASM|International Classification of Sleep Disorders, Vthird
[4]  
[Anonymous], 2018, F1000RES
[5]   From state dissociation to status dissociatus [J].
Antelmi, Elena ;
Ferri, Raffaele ;
Iranzo, Alex ;
Arnulf, Isabelle ;
Dauvilliers, Yves ;
Bhatia, Kailash P. ;
Liguori, Rocco ;
Schenck, Carlos H. ;
Plazzi, Giuseppe .
SLEEP MEDICINE REVIEWS, 2016, 28 :5-17
[6]   Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset [J].
Aran, Adi ;
Lin, Ling ;
Nevsimalova, Sona ;
Plazzi, Giuseppe ;
Hong, Seung Chul ;
Weiner, Karin ;
Zeitzer, Jamie ;
Mignot, Emmanuel .
SLEEP, 2009, 32 (08) :979-983
[7]   Sleep and psychiatric abnormalities in Gullian Barré Syndrome [J].
Bahnasy W.S. ;
El-Heneedy Y.A.E. ;
El-Shamy A.M. ;
Badr M.Y. ;
Amer R.A. ;
Ibrahim I.S.E. .
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 54 (1)
[8]   Autoantibodies against IgLON5: Two new cases [J].
Bahtz, Ramona ;
Teegen, Bianca ;
Borowski, Kathrin ;
Probst, Christian ;
Bloecker, Inga-Madeleine ;
Fechner, Kai ;
Parigger, Silvia ;
Daniel, Gerhard ;
Bruecke, Thomas ;
Lauenstein, Annesophie ;
Schrank, Bertold ;
Stoecker, Winfried ;
Komorowski, Lars .
JOURNAL OF NEUROIMMUNOLOGY, 2014, 275 (1-2) :8-8
[9]   Management of Narcolepsy [J].
Barateau, Lucie ;
Lopez, Regis ;
Dauvilliers, Yves .
CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2016, 18 (10)
[10]   Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody [J].
Barnett, M ;
Prosser, J ;
Sutton, I ;
Halmagyi, GM ;
Davies, L ;
Harper, C ;
Dalmau, J .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (02) :222-225