Synthesis, characterization, and bio-activity evaluation of thiourea derivatives of epinephrine as antimicrobial and antioxidant agents: molecular docking studies

被引：10

作者：

Sudhamani, H. ^{[1
]}

Basha, S. K. Thaslim ^{[1
]}

Adam, S. ^{[2
]}

Bhaskar, B. Vijay ^{[3
]}

Raju, C. Naga ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Inst Frontier Technol, Nanotechnol Lab, RARS, Tirupati 517502, Andhra Pradesh, India

[3] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India

来源：

MONATSHEFTE FUR CHEMIE | 2017年 / 148卷 / 08期

关键词：

Epinephrine; Isothiocyanates; Antimicrobial activity; DPPH; FRAP; Superoxide anion scavenging activity; Catalase activity; Molecular docking studies; NADPH oxidase; PHAGOCYTE NADPH OXIDASE; BIOLOGICAL EVALUATION; L-ADRENALINE; IN-VITRO; PLASMA; CHILDREN; MOIETY; MUSCLE;

D O I：

10.1007/s00706-017-1938-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On account of the antimicrobial activity of epinephrine, it is elegantly designed and synthesized in high yield a novel plethora of thiourea derivatives by treating with various biopotent isothiocyanates. The chemical structures of the new compounds were characterized by FT-IR, H-1, C-13 NMR, LC-MS, and HR-MS and they have been evaluated for their in vitro antimicrobial and antioxidant activities (DPPH, FRAP, superoxide anion scavenging, and catalase activity). Nitro- and chloro-substituted compounds exhibited high antimicrobial activity. A molecular modeling study was performed on NADPH oxidase to investigate the hypothetical binding mode of the most active antioxidant agents and binding conformers were proposed.

引用

页码：1525 / 1537

页数：13

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