Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction

被引：112

作者：

Rodriguez, Raphael ^{[1
]}

Pantos, G. Dan ^{[1
]}

Goncalves, Diana P. N. ^{[1
]}

Sanders, Jeremy K. M. ^{[1
]}

Balasubramanian, Shankar ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期

关键词：

conformation analysis; DNA; G-quadruplex; self-assembly; supramolecular chemistry;

D O I：

10.1002/anie.200605075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Under control: An anthracene polyammonium derivative induces folding of the highly polymorphic human telomeric DNA into a single parallel G-quadruplex conformer through an unusual mode of interaction. The sequential use of this ligand and a porphyrazine allows controlled conformational switching of the quadruplex between parallel and antiparallel conformations. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5405 / 5407

页数：3

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