Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction

被引：112

作者：

Rodriguez, Raphael ^{[1
]}

Pantos, G. Dan ^{[1
]}

Goncalves, Diana P. N. ^{[1
]}

Sanders, Jeremy K. M. ^{[1
]}

Balasubramanian, Shankar ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期

关键词：

conformation analysis; DNA; G-quadruplex; self-assembly; supramolecular chemistry;

D O I：

10.1002/anie.200605075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Under control: An anthracene polyammonium derivative induces folding of the highly polymorphic human telomeric DNA into a single parallel G-quadruplex conformer through an unusual mode of interaction. The sequential use of this ligand and a porphyrazine allows controlled conformational switching of the quadruplex between parallel and antiparallel conformations. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5405 / 5407

页数：3

共 16 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].

Alberti, P ;

Mergny, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573

[2] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution [J].

Ambrus, Attila ;

Chen, Ding ;

Dai, Jixun ;

Bialis, Tiffanie ;

Jones, Roger A. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2723-2735

[3] DIALKYLAMMONIUM ION CROWN-ETHER COMPLEXES - THE FORERUNNERS OF A NEW FAMILY OF INTERLOCKED MOLECULES [J].

ASHTON, PR ;

CAMPBELL, PJ ;

CHRYSTAL, EJT ;

GLINK, PT ;

MENZER, S ;

PHILP, D ;

SPENCER, N ;

STODDART, JF ;

TASKER, PA ;

WILLIAMS, DJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (17) :1865-1869

[4]

ASHTON PR, 1995, ANGEW CHEM, V107, P1997

[5] G-quartets 40 years later:: From 5′-GMP to molecular biology and supramolecular chemistry [J].

Davis, JT .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (06) :668-698

[6]

Davis JT., 2004, ANGEW CHEM, V116, P684, DOI DOI 10.1021/ACS.BIOMAC.8B00818

[7] Tetramethylpyridiniumporphyrazines -: a new class of G-quadruplex inducing and stabilising ligands [J].

Goncalves, Diana P. N. ;

Rodriguez, Raphael ;

Balasubramanian, Shankar ;

Sanders, Jeremy K. M. .

CHEMICAL COMMUNICATIONS, 2006, (45) :4685-4687

[8]

Hud NV, 2006, RSC BIOMOL SCI, P100

[9] Prevalence of quadruplexes in the human genome [J].

Huppert, JL ;

Balasubramanian, S .

NUCLEIC ACIDS RESEARCH, 2005, 33 (09) :2908-2916

[10] THERMODYNAMICS AND STRUCTURE OF A DNA TETRAPLEX - A SPECTROSCOPIC AND CALORIMETRIC STUDY OF THE TETRAMOLECULAR COMPLEXES OF D(TG3T) AND D(TG3T2G3T) [J].

JIN, RZ ;

GAFFNEY, BL ;

WANG, C ;

JONES, RA ;

BRESLAUER, KJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8832-8836

← 1 2 →