Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment

被引：32

作者：

Rocha, Sonia ^{[1
]}

Lucas, Mariana ^{[1
]}

Ribeiro, Daniela ^{[1
]}

Corvo, M. Luisa ^{[2
]}

Fernandes, Eduarda ^{[1
]}

Freitas, Marisa ^{[1
]}

机构：

[1] Univ Porto, Fac Pharm, Dept Chem Sci, LAQV,REQUIMTE,Lab Appl Chem, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[2] Univ Lisbon, Fac Farm, Res Inst Med, P-1649003 Lisbon, Portugal

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 169卷

关键词：

Diabetes mellitus; Polyphenols; Nano-based drug delivery systems; Drug targeting; NANOSTRUCTURED LIPID CARRIERS; IRON-OXIDE NANOPARTICLES; DIETARY POLYPHENOLS; GOLD NANOPARTICLES; BIOLOGICAL-ACTIVITIES; POLYMERIC MICELLES; IN-VITRO; INSULIN; QUERCETIN; NANOCARRIERS;

D O I：

10.1016/j.phrs.2021.105604

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetes mellitus is one of the biggest health emergencies of the 21st century worldwide, characterized by deficiency in insulin secretion and/or action, leading to hyperglycemia. Despite the currently available antidiabetic therapeutic options, 4.2 million people died in 2019 due to diabetes. Thus, new effective interventions are required. Polyphenols are plant secondary metabolites and have been recognized for their vast number of biological activities, including potential antidiabetic effects. However, the poor bioavailability and high metabolization of polyphenols restrict their biological effects in vivo. Nanotechnology is a promising area of research to improve the therapeutic effect of several compounds. Therefore, this review provides an overview of the literature about the utility of nano-based drug delivery systems as vehicles of polyphenols in diabetes treatment. It was possible to conclude that, in general, nano-based drug delivery systems can potentiate the beneficial antidiabetic properties of polyphenols, when compared with the free compounds, opening a new field of research in diabetology.

引用

页数：25

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