Plant-Based Biosynthesis of Copper/Copper Oxide Nanoparticles: An Update on Their Applications in Biomedicine, Mechanisms, and Toxicity

被引：144

作者：

Letchumanan, Devanthiran ^{[1
]}

Sok, Sophia P. M. ^{[1
,2
]}

Ibrahim, Suriani ^{[3
]}

Nagoor, Noor Hasima ^{[1
,2
]}

Arshad, Norhafiza Mohd ^{[1
]}

机构：

[1] Univ Malaya, Ctr Res Biotechnol Agr, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Inst Biol Sci Genet & Mol Biol, Fac Sci, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Dept Mech Engn, Fac Engn, Kuala Lumpur 50603, Malaysia

来源：

BIOMOLECULES | 2021年 / 11卷 / 04期

关键词：

copper; copper oxide; green synthesis; nanoparticles; biomedicine; mechanism; toxicity; GREEN SYNTHESIS; COPPER NANOPARTICLES; LEAF EXTRACT; ANTICANCER ACTIVITY; CUO NANOPARTICLES; SILVER NANOPARTICLES; CANCER-CELLS; PHOTOCATALYTIC ACTIVITY; METAL NANOPARTICLES; ANTIBACTERIAL;

D O I：

10.3390/biom11040564

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plants are rich in phytoconstituent biomolecules that served as a good source of medicine. More recently, they have been employed in synthesizing metal/metal oxide nanoparticles (NPs) due to their capping and reducing properties. This green synthesis approach is environmentally friendly and allows the production of the desired NPs in different sizes and shapes by manipulating parameters during the synthesis process. The most commonly used metals and oxides are gold (Au), silver (Ag), and copper (Cu). Among these, Cu is a relatively low-cost metal that is more cost-effective than Au and Ag. In this review, we present an overview and current update of plant-mediated Cu/copper oxide (CuO) NPs, including their synthesis, medicinal applications, and mechanisms. Furthermore, the toxic effects of these NPs and their efficacy compared to commercial NPs are reviewed. This review provides an insight into the potential of developing plant-based Cu/CuO NPs as a therapeutic agent for various diseases in the future.

引用

页数：27

共 132 条

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