Molecular targets of epigenetic regulation and effectors of environmental influences

被引：77

作者：

Choudhuri, Supratim ^{[1
,2
]}

Cui, Yue ^{[3
]}

Klaassen, Curtis D. ^{[3
]}

机构：

[1] US FDA, Ctr Food Safety & Appl Nutr, Off Food Addit Safety, Div Biotechnol, College Pk, MD 20740 USA

[2] GRAS Notice Review, College Pk, MD USA

[3] Univ Kansas, Med Ctr, Dept Pharmacol & Toxicol, Kansas City, KS 66103 USA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2010年 / 245卷 / 03期

关键词：

DNA; Drug-metabolizing enzymes; Histone modifications; Methylation; Transporters ncRNA; miRNA; DIETARY-PROTEIN RESTRICTION; DNA METHYLATION; TRANSCRIPTIONAL REPRESSOR; PROMOTER HYPERMETHYLATION; TRANSGENERATIONAL ACTIONS; ABERRANT EXPRESSION; TISSUE DISTRIBUTION; GENE-EXPRESSION; CPG METHYLATION; PREGNANT RATS;

D O I：

10.1016/j.taap.2010.03.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The true understanding of what we currently define as epigenetics evolved over time as our knowledge on DNA methylation and chromatin modifications and their effects on gene expression increased. The current explosion of research on epigenetics and the increasing documentation of the effects of various environmental factors on DNA methylation, chromatin modification, as well as on the expression of small non-coding RNAs (ncRNAs) have expanded the scope of research on the etiology of various diseases including cancer. The current review briefly discusses the molecular mechanisms of epigenetic regulation and expands the discussion with examples on the role of environment, such as the immediate environment during development, in inducing epigenetic changes and modulating gene expression. Published by Elsevier Inc.

引用

页码：378 / 393

页数：16

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