Anterior Cingulate Volumetric Alterations in Treatment-Naive Adults With ADHD A Pilot Study

被引：48
作者：
Makris, Nikos [1 ,3 ]
Seidman, Larry J. [2 ,9 ]
Valera, Eve M.
Biederman, Joseph [5 ,6 ]
Monuteaux, Michael C. [5 ,6 ]
Kennedy, David N.
Caviness, Verne S., Jr.
Bush, George
Crum, Katherine
Brown, Ariel B. [3 ,7 ,8 ]
Faraone, Stephen V. [4 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Morphometr Anal, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, Cambridge, MA 02138 USA
[3] Boston Univ, Sch Med, Boston, MA 02215 USA
[4] SUNY Upstate Med Univ, Syracuse, NY USA
[5] Massachusetts Gen Hosp, ADHD, Charlestown, MA 02129 USA
[6] Massachusetts Gen Hosp, Clin & Res Programs Pediat Psychopharmacol, Charlestown, MA 02129 USA
[7] Massachusetts Gen Hosp, Pediat Psychopharmacol Clin, Charlestown, MA 02129 USA
[8] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[9] Massachusetts Gen Hosp, Boston, MA 02114 USA
来源：
JOURNAL OF ATTENTION DISORDERS | 2010年 / 13卷 / 04期
基金：
美国国家卫生研究院;
关键词：
ADHD; treatment-naive ADHD; ACC; volumetry; morphometry; MRI; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; MOTOR CONTROL; CHILDREN; MRI; CORTEX; ABNORMALITIES; BRAIN; ADOLESCENTS; NETWORKS;
D O I：
10.1177/1087054709351671
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naive adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naive adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naive group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413)
引用
收藏
页码：407 / 413
页数：7
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