The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor

被引：47

作者：

McCarthy, MJ

Crowther, M

Bell, PRF

Brindle, NPJ

机构：

[1] Univ Leicester, Dept Surg, Leicester LE2 7LX, Leics, England

[2] Univ Leicester, Inst Cardiovasc Res, RKCSB, Leicester LE2 7LX, Leics, England

来源：

FEBS LETTERS | 1998年 / 423卷 / 03期

基金：

英国惠康基金;

关键词：

angiogenesis; growth factor; hypoxia; receptor;

D O I：

10.1016/S0014-5793(98)00122-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The receptor tyrosine kinase tie-1 is essential for angiogenesis where it appears to have a role in vessel maturation, Here we have examined the effects of hypoxia and vascular endothelial growth factor (VEGF) on the level of tie-1 protein expressed in bovine aortic endothelial cells, Both hypoxia (2% O-2) and VEGF were found to increase tie-1 in a time-dependent manner, Hypoxic induction was direct and effects of hypoxia and VEGF were not additive. Experiments with actinomycin D indicate that these activators regulate tie-1 at the transcriptional level. (C) 1998 Federation of European Biochemical Societies.

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页码：334 / 338

页数：5

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