Novel IL-12 family members shed light on the orchestration of Th1 responses

被引：232

作者：

Brombacher, F

Kastelein, RA

Alber, G

机构：

[1] Univ Leipzig, Coll Vet Med, Inst Immunol, D-04103 Leipzig, Germany

[2] Univ Cape Town, Groote Schuur Hosp, Div Immunol, ZA-7925 Cape Town, South Africa

[3] DNAX Res Inst Molec & Cellular Biol Inc, Palo Alto, CA 94304 USA

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1471-4906(03)00067-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess. Besides IL-12, other p40-dependent molecules exist that orchestrate Th1 responses. Homodimeric p40 can act as an IL-12 antagonist by competing for its receptor. Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-related protein p19. This heterodimer is known as IL-23 and has activities on memory T cells. Finally, IL-27, the latest addition to this family, is a heterodimer composed of the p40-related protein EBI3 (Epstein-Barr virus-induced gene 3) and the p35-related protein p28. IL-27 is involved in early Th1 initiation.

引用

页码：207 / 212

页数：6

共 66 条

[1] T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
Afkarian, M
Sedy, JR
Yang, J
Jacobson, NG
Cereb, N
Yang, SY
Murphy, TL
Murphy, KM
[J]. NATURE IMMUNOLOGY, 2002, 3 (06) : 549 - 557
[2] Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
Aggarwal, S
Ghilardi, N
Xie, MH
de Sauvage, FJ
Gurney, AL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) : 1910 - 1914
[3] IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes
Brombacher, F
Dorfmüller, A
Magram, J
Dai, WJ
Köhler, G
Wunderlin, A
Palmer-Lehmann, K
Gately, MK
Alber, G
[J]. INTERNATIONAL IMMUNOLOGY, 1999, 11 (03) : 325 - 332
[4] The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40
Carr, JA
Rogerson, JA
Mulqueen, MJ
Roberts, NA
Nash, AA
[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (10) : 1145 - 1152
[5] Development of Th1-type immune responses requires the type I cytokine receptor TCCR
Chen, Q
Ghilardi, N
Wang, H
Baker, T
Xie, MH
Gurney, A
Grewal, IS
de Sauvage, FJ
[J]. NATURE, 2000, 407 (6806) : 916 - 920
[6] Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
Cooper, AM
Kipnis, A
Turner, J
Magram, J
Ferrante, J
Orme, IM
[J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (03) : 1322 - 1327
[7] Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
Cooper, AM
Magram, J
Ferrante, J
Orme, IM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (01) : 39 - 45
[8] PRODUCTION OF NATURAL-KILLER-CELL STIMULATORY FACTOR (INTERLEUKIN-12) BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS
DANDREA, A
RENGARAJU, M
VALIANTE, NM
CHEHIMI, J
KUBIN, M
ASTE, M
CHAN, SH
KOBAYASHI, M
YOUNG, D
NICKBARG, E
CHIZZONITE, R
WOLF, SF
TRINCHIERI, G
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) : 1387 - 1398
[9] Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
Decken, K
Köhler, G
Palmer-Lehmann, K
Wunderlin, A
Mattner, F
Magram, J
Gately, MK
Alber, G
[J]. INFECTION AND IMMUNITY, 1998, 66 (10) : 4994 - 5000
[10] A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
Devergne, O
Hummel, M
Koeppen, H
LeBeau, MM
Nathanson, EC
Kieff, E
Birkenbach, M
[J]. JOURNAL OF VIROLOGY, 1996, 70 (02) : 1143 - 1153

← 1 2 3 4 5 6 7 →