COMBINED CARDIORENAL TRANSPLANT IN HEART AND ADVANCED RENAL DISEASE

被引:0
作者
Peradejordi Lastras, Margarita [1 ]
Ethel Favaloro, Liliana [1 ]
Marcela Fortunato, Rita [2 ]
Gutierrez, Luis [2 ]
Eduardo Rabin, Gabriel [2 ]
Oscar Absi, Daniel [1 ]
Abud, Jose [1 ]
Raffaelli, Hector [2 ]
Marrugat, Rodolfo [2 ]
Fraguas, Hugo [2 ]
Rene Favaloro, Roberto [1 ]
Raffaele, Pablo [2 ]
Mario Bertolotti, Alejandro [1 ]
机构
[1] Hosp Univ Fdn Favaloro, Div Trasplante Intratoracico & Insuficiencia Card, Buenos Aires, DF, Argentina
[2] Hosp Univ Fdn Favaloro, Unidad Renal, Buenos Aires, DF, Argentina
来源
REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE | 2015年 / 35卷 / 04期
关键词
cardiac transplant; renal transplant; cardiorenal transplant; combined transplant; renal failure; SINGLE-DONOR ALLOGRAFTS; KIDNEY-TRANSPLANTATION; INTERNATIONAL SOCIETY; LUNG TRANSPLANTATION; UNITED-NETWORK; FAILURE; INSUFFICIENCY; REGISTRY; ORGAN; MULTIORGAN;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Renal failure (RF) is a post cardiac transplantation predictor of morbimortality. The combined cardiorenal transplant (CCRTx) in cardiac transplantation (CTx) candidates with chronic renal disease is a therapeutic option. Our aim was to evaluate the CCRTx follow up outcomes in a single Centre. Material and methods: Between 2/1993 and 12/2014 we performed 442 CTx. Since 2006, 20 patients (p) underwent CCRTx using allografts from the same donor. The inclusion criteria were: RF with CrCl <= 40 mil/min or dialysis requirement in CTx candidates. All p received Thymoglobulin and immunosuppression with tacrolimus, mycophenolate mofetil and steroids. Median follow up: 46 months (7-96). Results: Mean age: 58 +/- 7 years, 85% were male. Mean Creatinine (Cr): 3,1 +/- 2,5 mg/dl and ClCr 27,5+10 mil/min. Three p required dialysis during the pre-transplantation phase and 4 p were under chronic dialysis. Etiologies: cardiomyopathies: coronary 10 p, noncoronary 9 p and re CTx, 1 p; nephropathies: nephroangiosclerosis 5 p, cardiorenal syndrome 10 p, diabetes 2 p, glomerulopathy 1 p, polycystosis 1 p and toxic nephritis 1 p. At 30 days and 1 year post CCRTx, Cr was 1,2 +/- 0,4 mg/dl and 1,1 +/- 0,2 mg/dl respectively. In-hospital mortality was 3/20 p (15%), 2 p due to sepsis and 1 p due to cardiac graft failure. Late mortality 5/17 p (29 %), 4p due to sepsis and 1 p due to liver sarcoma. Survival at 1 and 3 years was 76 and 72%, respectively. Conclusions: In our series CCRTx was a safe and effective treatment for CTx candidates with CrCl < 40 ml/min.
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收藏
页码:188 / 195
页数:8
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