4-HYDROXY-2-QUINOLONES 173. 1-R-3-(2-DIETHYLAMINOETHYL)-1H-QUINAZOLINE-2,4-DIONE HYDROCHLORIDES AS POTENTIAL LOCAL ANESTHETIC AGENTS

被引：6

作者：

Ukrainets, I. V. ^{[1
]}

Kravtsova, V. V. ^{[1
]}

Tkach, A. A. ^{[1
]}

Mamchur, V. I. ^{[2
]}

Kovalenko, E. Yu. ^{[2
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] Dnepropetrovsk State Med Acad, UA-49044 Dnepropetrovsk, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2010年 / 46卷 / 01期

关键词：

isatoic anhydride; local anesthetics; alkylation; 1H-quinazoline-2,4-diones; X-ray structural analysis;

D O I：

10.1007/s10593-010-0475-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.

引用

页码：96 / 105

页数：10

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