Selective Inhibition of HDAC6 regulates preferential cytotoxicity in cancer cells by modulating p53 and Hsp90 stability

被引:0
|
作者
Kwon, So Hee [1 ]
机构
[1] Yonsei Univ, Inchon, South Korea
关键词
D O I
10.1158/1538-7445.AM2015-5324
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5324
引用
收藏
页数:3
相关论文
共 50 条
  • [1] SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
    D Li
    N D Marchenko
    U M Moll
    Cell Death & Differentiation, 2011, 18 : 1904 - 1913
  • [2] SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
    Li, D.
    Marchenko, N. D.
    Moll, U. M.
    CELL DEATH AND DIFFERENTIATION, 2011, 18 (12): : 1904 - 1913
  • [3] p53 Regulates Hsp90β during arsenite-induced cytotoxicity in glutathione-deficient cells
    Habib, Geetha M.
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2009, 481 (01) : 101 - 109
  • [4] HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer
    Ai, Junkui
    Wang, Yujuan
    Dar, Javid A.
    Liu, June
    Liu, Lingqi
    Nelson, Joel B.
    Wang, Zhou
    MOLECULAR ENDOCRINOLOGY, 2009, 23 (12) : 1963 - 1972
  • [5] Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90
    Qingwei Meng
    Xuesong Chen
    Lichun Sun
    Changhong Zhao
    Guangjie Sui
    Li Cai
    Molecular and Cellular Biochemistry, 2011, 348 : 165 - 171
  • [6] Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90
    Meng, Qingwei
    Chen, Xuesong
    Sun, Lichun
    Zhao, Changhong
    Sui, Guangjie
    Cai, Li
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 348 (1-2) : 165 - 171
  • [7] HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
    Kovacs, JJ
    Murphy, PJM
    Gaillard, S
    Zhao, XA
    Wu, JT
    Nicchitta, CV
    Yoshida, M
    Toft, DO
    Pratt, WB
    Yao, TP
    MOLECULAR CELL, 2005, 18 (05) : 601 - 607
  • [8] HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
    Rao, Rekha
    Fiskus, Warren
    Yang, Yonghua
    Lee, Pearl
    Joshi, Rajeshree
    Fernandez, Pravina
    Mandawat, Aditya
    Atadja, Peter
    Bradner, James E.
    Bhalla, Kapil
    BLOOD, 2008, 112 (05) : 1886 - 1893
  • [9] Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma
    Regan, Paul L.
    Jacobs, Joshua
    Wang, Gerald
    Torres, Jaime
    Edo, Robby
    Friedmann, Jennifer
    Tang, Xao X.
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2011, 38 (01) : 105 - 112
  • [10] Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization
    Peng, YH
    Chen, LH
    Li, CG
    Lu, WG
    Chen, JD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) : 40583 - 40590