Nanocarrier vaccines for SARS-CoV-2

被引：61

作者：

Machhi, Jatin ^{[1
]}

Shahjin, Farah ^{[1
]}

Das, Srijanee ^{[2
]}

Patel, Milankumar ^{[1
]}

Abdelmoaty, Mai Mohamed ^{[3
,4
]}

Cohen, Jacob D. ^{[1
]}

Singh, Preet Amol ^{[5
]}

Baldi, Ashish ^{[5
]}

Bajwa, Neha ^{[5
]}

Kumar, Raj ^{[6
]}

Vora, Lalit K. ^{[7
]}

Patel, Tapan A. ^{[8
]}

Oleynikov, Maxim D. ^{[1
]}

Soni, Dhruvkumar ^{[3
]}

Yeapuri, Pravin ^{[1
]}

Mukadam, Insiya ^{[3
]}

Chakraborty, Rajashree ^{[1
]}

Saksena, Caroline G. ^{[1
]}

Herskovitz, Jonathan ^{[2
]}

Hasan, Mahmudul ^{[3
]}

Oupicky, David ^{[6
]}

Das, Suvarthi ^{[9
]}

Donnelly, Ryan F. ^{[7
]}

Hettie, Kenneth S. ^{[10
]}

Chang, Linda ^{[11
,12
]}

Gendelman, Howard E. ^{[1
,2
,3
]}

Kevadiya, Bhavesh D. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Coll Med, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Coll Med, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[3] Univ Nebraska Med Ctr, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 68198 USA

[4] Natl Res Ctr, Therapeut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza, Egypt

[5] Maharaja Ranjit Singh Punjab Tech Univ, Dept Pharmaceut Sci & Technol, Bathinda, Punjab, India

[6] Univ Nebraska Med Ctr, Ctr Drug Delivery & Nanomed, Dept Pharmaceut Sci, Omaha, NE 68198 USA

[7] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland

[8] Charotar Univ Sci & Technol CHARUSAT, PD Patel Inst Appl Sci PDPIAS, Dept Biol Sci, Anand 388421, Gujarat, India

[9] Stanford Univ, Stanford Med Sch, Dept Med, Palo Alto, CA 94304 USA

[10] Stanford Univ, Dept Radiol, Dept Otolaryngol Head & Neck Surg, Mol Imaging Program Stanford MIPS, Palo Alto, CA 94304 USA

[11] Univ Maryland, Sch Med, Dept Diagnost Radiol, Baltimore, MD 21201 USA

[12] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 171卷

基金：

美国国家卫生研究院;

关键词：

SARS-CoV-2; COVID-19; vaccine; Nanovaccine; mRNA vaccine; VIRUS-LIKE PARTICLES; ACUTE-RESPIRATORY-SYNDROME; RECEPTOR-BINDING DOMAIN; ATTENUATED MEASLES-VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; CORONAVIRUS SPIKE PROTEIN; ZOSTER SUBUNIT VACCINE; MESSENGER-RNA VACCINE; NEUTRALIZING ANTIBODIES; SARS-CORONAVIRUS;

D O I：

10.1016/j.addr.2021.01.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The SARS-CoV-2 global pandemic has seen rapid spread, disease morbidities and death associated with substan-tive social, economic and societal impacts. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on attenuating the acute respiratory distress syndrome. No curative therapies exist. Vaccines re-main the best hope for disease control and the principal global effort to end the pandemic. Herein, we summarize those developments with a focus on the role played by nanocarrier delivery. Crown Copyright (c) 2021 Published by Elsevier B.V. All rights reserved.

引用

页码：215 / 239

页数：25

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