Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells

被引：28

作者：

Kim, Seung Hyun ^{[2
]}

Park, Jung Hyun ^{[1
]}

Kim, Tae Bum ^{[1
]}

Lee, Hyang Hwa ^{[1
]}

Lee, Ki Yong ^{[1
]}

Kim, Young Choong ^{[1
]}

Sung, Sang Hyun ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Elcomsci Co Ltd, Inst Life Sci, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 09期

关键词：

Betula platyphylla; beta-Hexosaminidase; RBL-2H3; cells; Arylbutanoid; Diarylheptanoid; VAR; JAPONICA; DIARYLHEPTANOID GLYCOSIDES; INNER BARK; CONSTITUENTS; RUBRA;

D O I：

10.1016/j.bmcl.2010.03.053

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and 12 were isolated and assigned for the first time. Compounds 1, 2, 3, 5, 10, and 12 showed remarkable inhibitory activity against the degranulation of RBL-2H3 by antigen stimulation in a dose dependent manner at the concentrations ranging from 10 mu M to 100 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2824 / 2827

页数：4

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