Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells

被引：26
|
作者：
Kim, Seung Hyun [2 ]
Park, Jung Hyun [1 ]
Kim, Tae Bum [1 ]
Lee, Hyang Hwa [1 ]
Lee, Ki Yong [1 ]
Kim, Young Choong [1 ]
Sung, Sang Hyun [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[2] Elcomsci Co Ltd, Inst Life Sci, Seoul 151742, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 09期
关键词：
Betula platyphylla; beta-Hexosaminidase; RBL-2H3; cells; Arylbutanoid; Diarylheptanoid; VAR; JAPONICA; DIARYLHEPTANOID GLYCOSIDES; INNER BARK; CONSTITUENTS; RUBRA;
D O I：
10.1016/j.bmcl.2010.03.053
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and 12 were isolated and assigned for the first time. Compounds 1, 2, 3, 5, 10, and 12 showed remarkable inhibitory activity against the degranulation of RBL-2H3 by antigen stimulation in a dose dependent manner at the concentrations ranging from 10 mu M to 100 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2824 / 2827
页数：4
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