Porous CuxCoyS Supraparticles for In Vivo Telomerase Imaging and Reactive Oxygen Species Generation

被引：17
|
作者：
Li, Si [1 ,2 ]
Xu, Liguang [1 ,2 ]
Hao, Changlong [1 ,2 ]
Sun, Maozhong [1 ,2 ]
Wu, Xiaoling [1 ,2 ]
Kuang, Hua [1 ,2 ]
Xu, Chuanlai [1 ,2 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[2] Jiangnan Univ, Int Joint Res Lab Biointerface & Biodetect, Wuxi 214122, Jiangsu, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 52期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
bioimaging; porous materials; reactive oxygen species; supraparticles; telomerase; MONODISPERSE; CATALYSTS; CELLS;
D O I：
10.1002/anie.201911770
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, we successfully synthesized CuxCoyS supraparticles (SPs) on the nanoscale featuring multiple pores inside and strong absorption from 400 to 900 nm. Porous CuxCoyS SPs produced the highest reactive oxygen species (ROS) yield (1.39) when illuminated with near-infrared (NIR) light. Furthermore, we demonstrated that CuxCoyS SPs could be used to identify cancer cells through intracellular telomerase-responsive fluorescence (FL) imaging in living cells. Because the CuxCoyS SPs were associated with telomerase-responsive bioimaging and high ROS production, they can be efficiently used in the diagnosis and therapy of tumors with high selectivity and excellent therapeutic effects in vivo. This study provides a new vision for the creation of multifunctional SPs, which can be used as cellular sensors and control tools for pathologies across a broad range of biological systems.
引用
收藏
页码：19067 / 19072
页数：6
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