Relation of Body Mass Index to Development of Atrial Fibrillation in Hispanics, Blacks, and Non-Hispanic Whites

被引:6
作者
Shulman, Eric [1 ]
Chudow, Jay J. [1 ]
Shah, Tina [1 ]
Shah, Krina [1 ]
Peleg, Ariel [1 ]
Nevelev, Dmitriy [1 ]
Kargoli, Faraj [1 ]
Zaremski, Lynn [1 ]
Berardi, Cecilia [1 ]
Natale, Andrea [1 ]
Romero, Jorge [1 ]
Di Biase, Luigi [1 ]
Fisher, John [1 ]
Krumerman, Andrew [1 ]
Ferrick, Kevin J. [1 ]
机构
[1] Montefiore Med Ctr, Dept Med, Div Cardiol, Bronx, NY 10467 USA
关键词
RISK-FACTORS; AFRICAN-AMERICANS; OBESITY; VALIDATION; ADULTS;
D O I
10.1016/j.amjcard.2018.01.039
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
No previous studies have examined the interaction between body mass index (BMI) and race/ethnicity with the risk of atrial fibrillation (AF). We retrospectively followed 48,323 persons free of AF (43% Hispanic, 37% black, and 20% white; median age 60 years) for subsequent incident AF (ascertained from electrocardiograms). BMI categories included very severely underweight (BMI <15 kg/m(2)), severely underweight (BMI 15.1 to 15.9 kg/m(2)), underweight (BMI 16 to 18.4 kg/m(2)), normal (BMI 18.5 to 24.9 kg/m(2)), overweight (BMI 25.0 to 29.9 kg/m(2)), moderately obese (BMI 30 to 34.9 kg/m(2)), severely obese (BMI 35 to 39.9 kg/m(2)), and very severely obese (BMI >40 kg/m(2)). Cox regression analysis controlled for baseline covariates: heart failure, gender, age, treatment for hypertension, diabetes, PR length, systolic blood pressure, left ventricular hypertrophy, socioeconomic status, use of beta blockers, calcium channel blockers, and digoxin. Over a follow-up of 13 years, 4,744 AF cases occurred. BMI in units of 10 was associated with the development of AF (adjusted hazard ratio 1.088, 95% confidence interval 1.048 to 1.130, p <0.01). When stratified by race/ethnicity, non-Hispanic whites compared with blacks and Hispanics had a higher risk of developing AF, noted in those whom BMI classes were overweight to severely obese. In conclusion, our study demonstrates that there exists a relation between obesity and race/ ethnicity for the development of AF. Non-Hispanic whites had a higher risk of developing AF compared with blacks and Hispanics. (C) 2018 Published by Elsevier Inc.
引用
收藏
页码:1177 / 1181
页数:5
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