Dealing with DNA lesions: When one cell cycle is not enough

被引：25

作者：

Lezaja, Aleksandra ^{[1
]}

Altmeyer, Matthias ^{[1
]}

机构：

[1] Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2021年 / 70卷

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

Genome stability; Cell cycle control; Mitosis; MiDAS; Telomere maintenance; ALT; Chromatin compartments; Liquid-liquid phase separation; REPLICATION STRESS; DAMAGE RESPONSE; GENOME; REPAIR; TELOMERES; RAD52; G1; ORGANIZATION; QUIESCENCE; INITIATION;

D O I：

10.1016/j.ceb.2020.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Subversion of genome integrity fuels cellular adaptation and is a prerequisite for organismal evolution, yet genomic lesions are also the harmful driving force of cancer and other agerelated human diseases. Genome integrity maintenance is inherently linked to genome organization and nuclear architecture, which are substantially remodeled during the cell cycle. Here we discuss recent findings on how actively dividing cells cope with endogenous genomic lesions that occur frequently at repetitive, heterochromatic, and late replicating regions as byproducts of genome duplication. We discuss how such lesions, rather than being resolved immediately when they occur, are dealt with in subsequent cell cycle phases, and even after mitotic cell division, and how this in turn affects genome organization, stability, and function.

引用

页码：27 / 36

页数：10

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