Regioselective Reactions of Highly Substituted Arynes

被引：112

作者：

Tadross, Pamela M. ^{[1
]}

Gilmore, Christopher D. ^{[1
]}

Bugga, Pradeep ^{[1
]}

Virgil, Scott C. ^{[1
]}

Stoltz, Brian M. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Arnold & Mabel Beckman Labs Chem Synth, Pasadena, CA 91125 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 06期

关键词：

REACTIVITY; ORIENTATION; ANNULATION; ACCESS; ACID;

D O I：

10.1021/ol1000796

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors In aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions Is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings.

引用

页码：1224 / 1227

页数：4

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