Search for Cancer Risk Factors with Microarray-Based Genome-Wide Association Studies

被引：5

作者：

Zhang, Lina ^{[1
,2
]}

Zhang, Wei ^{[3
]}

Chen, Kexin ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin, Peoples R China

[2] Tianjin Med Univ, Key Lab Breast Canc Prevent & Therapy, Minist Educ, Tianjin, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2010年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Single-nucleotide polymorphism; GWAS; Microarray; Breast cancer; Linkage disequilibrium; ACUTE LYMPHOBLASTIC-LEUKEMIA; COMMON SEQUENCE VARIANTS; POSITIVE BREAST-CANCER; URINARY-BLADDER CANCER; BASAL-CELL CARCINOMA; SUSCEPTIBILITY LOCUS; PROSTATE-CANCER; COLORECTAL-CANCER; LUNG-CANCER; CONFER SUSCEPTIBILITY;

D O I：

10.1177/153303461000900201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Large-scale genome-wide association studies (GWASs) have emerged as a powerful approach to identify genetic polymorphisms that are associated with risk of developing cancer and other complex diseases. Currently, microarrays are the genotype screening technology of choice in GWASs because they permit interrogation of more than one-million single-nucleotide polymorphisms (SNPs) at the same time. Many novel loci and genetic variants have been identified as markers of cancer risk in a series of recent reports. With improvement of microarray technologies, population-based GWASs coupled with more quantitative validation methods are poised to reveal, in a systematic manner, numerous small changes in complex genetic networks that in combination can have a major impact on a patient's risk of developing cancer. Here, we review recent advancement in GWAS in the search and identification of cancer risk factors.

引用

页码：107 / 121

页数：15

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