Mesenchymal Stem Cell Derived Extracellular Vesicles: A Role in Hematopoietic Transplantation?

被引:39
作者
De Luca, Luciana [1 ]
Trino, Stefania [1 ]
Laurenzana, Ilaria [1 ]
Lamorte, Daniela [1 ]
Caivano, Antonella [1 ]
Del Vecchio, Luigi [2 ,3 ]
Musto, Pellegrino [4 ]
机构
[1] IRCCS, Referral Canc Ctr Basilicata CROB, Lab Preclin & Translat Res, I-85028 Rionero In Vulture, Italy
[2] CEINGE Biotecnol Avanzate Scarl, I-80147 Naples, Italy
[3] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, Italy
[4] IRCCS, Referral Canc Ctr Basilicata CROB, Sci Direct, I-85028 Rionero In Vulture, Italy
关键词
mesenchymal stem cells; hematopoietic stem cell transplantation; graft versus host disease; extracellular vesicles; VERSUS-HOST-DISEASE; CORD BLOOD TRANSPLANTATION; STROMAL CELLS; BONE-MARROW; INDOLEAMINE 2,3-DIOXYGENASE; LYMPHOCYTE RECOVERY; PEDIATRIC-PATIENTS; EXOSOMAL MIRNAS; GRAFT FAILURE; MOUSE MODEL;
D O I
10.3390/ijms18051022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mesenchymal stem cells (MSCs) are a heterogeneous cellular population containing different progenitors able to repair tissues, support hematopoiesis, and modulate immune and inflammatory responses. Several clinical trials have used MSCs in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to prevent hematopoietic stem cell (HSC) engraftment failure, reduce aplasia post chemotherapy, and to control graft versus host disease (GvHD). The efficacy of MSCs is linked to their immune suppressive and anti-inflammatory properties primarily due to the release of soluble factors. Recent studies indicate that most of these effects are mediated by extracellular vesicles (EVs). MSC-EVs have therefore therapeutic effects in regenerative medicine, tumor inhibition, and immune-regulation. MSC-EVs may offer specific advantages for patient safety, such as lower propensity to trigger innate and adaptive immune responses. It has been also shown that MSC-EVs can prevent or treat acute-GvHD by modulating the immune-response and, combined with HSCs, may contribute to the hematopoietic microenvironment reconstitution. Finally, MSC-EVs may provide a new potential therapeutic option (e.g., transplantation, gene therapy) for different diseases, particularly hematological malignancies. In this review, we will describe MSC and MSC-EVs role in improving allo-HSCT procedures and in treating GvHD.
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页数:17
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共 125 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]   Single intra-arterial injection of mesenchymal stromal cells for treatment of steroid-refractory acute graft-versus-host disease: a pilot study [J].
Arima, Nobuyoshi ;
Nakamura, Fumiaki ;
Fukunaga, Akiko ;
Hirata, Hirokazu ;
Machida, Hiroko ;
Kouno, Shigene ;
Ohgushi, Hajime .
CYTOTHERAPY, 2010, 12 (02) :265-268
[3]   Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].
Augello, A ;
Tasso, R ;
Negrini, SM ;
Amateis, A ;
Indiveri, F ;
Cancedda, R ;
Pennesi, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490
[4]   Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy [J].
Baglio, Serena Rubina ;
Pegtel, D. Michiel ;
Baldini, Nicola .
FRONTIERS IN PHYSIOLOGY, 2012, 3
[5]   Cotransplantation of ex vivo-expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation [J].
Ball, Lynne M. ;
Bernardo, Maria Ester ;
Roelofs, Helene ;
Lankester, Arjan ;
Cometa, Angela ;
Egeler, R. Maarten ;
Locatelli, Franco ;
Fibbe, Willem E. .
BLOOD, 2007, 110 (07) :2764-2767
[6]   Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease [J].
Ball, Lynne M. ;
Bernardo, Maria E. ;
Roelofs, Helene ;
van Tol, Maarten J. D. ;
Contoli, Benedetta ;
Zwaginga, Jaap Jan ;
Avanzini, Maria Antonia ;
Conforti, Antonella ;
Bertaina, Alice ;
Giorgiani, Giovanna ;
Jol-van der Zijde, Cornelia M. ;
Zecca, Marco ;
Le Blanc, Katarina ;
Frassoni, Francesco ;
Egeler, Rudolph Maarten ;
Fibbe, Willem E. ;
Lankester, Arjan C. ;
Locatelli, Franco .
BRITISH JOURNAL OF HAEMATOLOGY, 2013, 163 (04) :501-509
[7]   Expansion and Homing of Umbilical Cord Blood Hematopoietic Stem and Progenitor Cells for Clinical Transplantation [J].
Bari, Sudipto ;
Seah, Kevin Kwee Hong ;
Poon, Zhiyong ;
Cheung, Alice Man Sze ;
Fan, Xiubo ;
Ong, Shin-Yeu ;
Li, Shang ;
Koh, Liang Piu ;
Hwang, William Ying Khee .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (06) :1008-1019
[8]   Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood-a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation [J].
Baron, Frederic ;
Labopin, Myriam ;
Ruggeri, Annalisa ;
Mohty, Mohamad ;
Sanz, Guillermo ;
Milpied, Noel ;
Bacigalupo, Andrea ;
Rambaldi, Alessandro ;
Bonifazi, Francesca ;
Bosi, Alberto ;
Sierra, Jorge ;
Yakoub-Agha, Ibrahim ;
Ribera Santasusana, Josep Maria ;
Gluckman, Eliane ;
Nagler, Arnon .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2015, 8
[9]   Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society [J].
Baron, Frederic ;
Zachee, Pierre ;
Maertens, Johan ;
Kerre, Tessa ;
Ory, Aurelie ;
Seidel, Laurence ;
Graux, Carlos ;
Lewalle, Philippe ;
Van Gelder, Michel ;
Theunissen, Koen ;
Willems, Evelyne ;
Emonds, Marie-Paule ;
De Becker, Ann ;
Beguin, Yves .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2015, 8
[10]   Mesenchymal stromal cells improve early lymphocyte recovery and T cell reconstitution after autologous hematopoietic stem cell transplantation in patients with malignant lymphomas [J].
Batorov, Egor V. ;
Shevela, Ekaterina Ya. ;
Tikhonova, Marina A. ;
Batorova, Dariya S. ;
Ushakova, Galina Yu. ;
Sizikova, Svetlana A. ;
Sergeevicheva, Vera V. ;
Gilevich, Andrey V. ;
Kryuchkova, Irina V. ;
Ostanin, Alexandr A. ;
Chernykh, Elena R. .
CELLULAR IMMUNOLOGY, 2015, 297 (02) :80-86