Solution-phase synthesis of a combinatorial monocyclic β-lactam library:: Potential protease inhibitors

被引：33

作者：

Pitlik, J ^{[1
]}

Townsend, CA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(97)10170-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 126-member library of monocyclic beta-lactams was generated in parallel fashion by solution-phase Ugi four-component condensation reaction between beta-amino acids, aldehydes, and isocyanides, The library was designed to identify potential human leukocyte elastase inhibitors. The approach is also capable of optimizing the lead compounds generated in the original library. (C) 1997 Elsevier Science Ltd.

引用

页码：3129 / 3134

页数：6

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