Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma

被引：58
|
作者：
Ji, Zhe [2 ]
Ai, Penghui [3 ]
Shao, Chen [4 ]
Wang, Tingjian [5 ]
Yan, Changxiang [5 ]
Ye, Ling [1 ]
Gu, Wei [1 ]
机构：
[1] Capital Med Univ, Sch Pharmaceut Sci, 10 Youanmenwaixitoutiao, Beijing 100069, Peoples R China
[2] Capital Med Univ, Sch Basic Med Sci, 10 Youanmenwaixitoutiao, Beijing 100069, Peoples R China
[3] Peoples Hosp Puyang, Dept Stroke Ctr, 252 Shengli Middle St, Puyang 457000, Henan, Peoples R China
[4] Capital Med Univ, Xuanwu Hosp, Dept Pharm, 45 Changchun St, Beijing 100053, Peoples R China
[5] Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, 50 Xiangshanyikesong, Beijing 100093, Peoples R China
来源：
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2018年 / 4卷 / 06期
基金：
中国国家自然科学基金;
关键词：
carbon dots (CDs); Mn doping; dual-modal; MR imaging; optical imaging; tiny brain gliomas; CONJUGATED MNO NANOPARTICLES; ASSISTED POLYOL SYNTHESIS; T-1 CONTRAST AGENT; QUANTUM DOTS; FLUORESCENCE; NANODOTS; SURGERY; STATES;
D O I：
10.1021/acsbiomaterials.7b01008
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Brain gliomas are life-threatening diseases with low survival rates. Early detection and accurate intraoperative location of brain gliomas is vital to improving the prognosis. Herein, we synthesized manganese (Mn)-doped carbon dots (CDs) as magnetic resonance (MR)/optical dual-modal imaging nanoprobes by a one-pot green microwave-assisted route. These ultra-small-sized Mn-doped CDs possess distinct excitation-dependent photoluminescent emissions, high r(1) relaxivity, and low cytotoxicity. The in vivo MR imaging and ex vivo optical imaging of mouse brain with tiny glioma demonstrate that the Mn-doped CDs could lead to an enhanced MR T-1 contrast effect in the tiny brain glioma region, disclosing the great promise of these Mn-doped CDs as MR/optical dual-modal imaging nanoprobes for detection and intraoperative location of tiny brain gliomas.
引用
收藏
页码：2089 / 2094
页数：11
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