Copper-catalyzed tandem synthesis of [1,2,3]triazolo[5,1-a]isoquinolines and their transformation to 1,3-disubstituted isoquinolines

被引：40

作者：

Hu, Yuan-Yuan ^{[1
]}

Hu, Jie ^{[1
]}

Wang, Xiang-Chuan ^{[1
]}

Guo, Li-Na ^{[1
]}

Shu, Xing-Zhong ^{[1
]}

Niu, Yan-Ning ^{[1
]}

Liang, Yong-Min ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

TETRAHEDRON | 2010年 / 66卷 / 01期

关键词：

MEDIATED ELECTROPHILIC CYCLIZATION; 3,4-DISUBSTITUTED ISOQUINOLINES; SUBSTITUTED ISOQUINOLINES; BENZODIAZEPINE-RECEPTOR; COUPLING REACTIONS; DERIVATIVES; PYRIDINES; ARYL; TRIAZOLOPYRIDINES; CYCLOADDITION;

D O I：

10.1016/j.tet.2009.11.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Azido-3-(2-iodophenyl)acrylates react with terminal alkynes in the presence of a copper(II) catalyst without ligands to give a wide range of [1,2,3]triazolo[5,1-a]isoquinolines in good yields. These compounds favor expulsion of N-2 in refluxed acetic acid to form 1,3-disubstituted isoquinolines. The procedure is simple, economical, and efficient. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：80 / 86

页数：7

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