Copper-catalyzed tandem synthesis of [1,2,3]triazolo[5,1-a]isoquinolines and their transformation to 1,3-disubstituted isoquinolines

被引:40
作者
Hu, Yuan-Yuan [1 ]
Hu, Jie [1 ]
Wang, Xiang-Chuan [1 ]
Guo, Li-Na [1 ]
Shu, Xing-Zhong [1 ]
Niu, Yan-Ning [1 ]
Liang, Yong-Min [1 ]
机构
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
关键词
MEDIATED ELECTROPHILIC CYCLIZATION; 3,4-DISUBSTITUTED ISOQUINOLINES; SUBSTITUTED ISOQUINOLINES; BENZODIAZEPINE-RECEPTOR; COUPLING REACTIONS; DERIVATIVES; PYRIDINES; ARYL; TRIAZOLOPYRIDINES; CYCLOADDITION;
D O I
10.1016/j.tet.2009.11.043
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
2-Azido-3-(2-iodophenyl)acrylates react with terminal alkynes in the presence of a copper(II) catalyst without ligands to give a wide range of [1,2,3]triazolo[5,1-a]isoquinolines in good yields. These compounds favor expulsion of N-2 in refluxed acetic acid to form 1,3-disubstituted isoquinolines. The procedure is simple, economical, and efficient. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:80 / 86
页数:7
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