CuI-Catalyzed conjugate addition of ethyl propiolate

被引：53

作者：

Fujimori, Shinji ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Lab Organ Chem, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 26期

基金：

澳大利亚研究理事会;

关键词：

alkynes; asymmetric synthesis; copper; nucleophilic addition; synthetic methods;

D O I：

10.1002/anie.200701098

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) More functionality possible: The conjugate addition of ethyl propiolate to Meldrum's acid derived acceptors is described. These reactions proceed under mild conditions employing substoichiometric amounts of a copper(I) species generated in situ. When chiral acceptors are employed as substrates, the additions are stereoselective and provide the addition adduct with high diastereoselectivity. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：4964 / 4967

页数：4

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