CuI-Catalyzed conjugate addition of ethyl propiolate

被引：53
作者：
Fujimori, Shinji [1 ]
Carreira, Erick M. [1 ]
机构：
[1] ETH, Lab Organ Chem, CH-8093 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 26期
基金：
澳大利亚研究理事会;
关键词：
alkynes; asymmetric synthesis; copper; nucleophilic addition; synthetic methods;
D O I：
10.1002/anie.200701098
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) More functionality possible: The conjugate addition of ethyl propiolate to Meldrum's acid derived acceptors is described. These reactions proceed under mild conditions employing substoichiometric amounts of a copper(I) species generated in situ. When chiral acceptors are employed as substrates, the additions are stereoselective and provide the addition adduct with high diastereoselectivity. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4964 / 4967
页数：4
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