Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

被引：5

作者：

Peng, Wei ^{[1
,2
]}

Jewell, Jenna L. ^{[1
,3
,4
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[4] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

来源：

CURRENT BIOLOGY | 2020年 / 30卷 / 02期

关键词：

CRYO-EM STRUCTURE; CRYSTAL-STRUCTURE; COMPLEX REVEALS; RAG GTPASES; ACTIVATION; MECHANISM; TORC1;

D O I：

10.1016/j.cub.2019.11.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

引用

页码：R89 / R91

页数：3

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