Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

被引：69

作者：

Ito, Tetsuhide

Tanaka, Masao

Sasano, Hironobu

Osamura, Yoshiyuki R.

Sasaki, Iwao

Kimura, Wataru

Takano, Koji

Obara, Takao

Ishibashi, Miyuki

Nakao, Kazuwa

Doi, Ryuichiro

Shimatsu, Akira

Nishida, Toshirou

Komoto, Izumi

Hirata, Yukio

Imamura, Masayuki

Kawabe, Ken

Nakamura, Kazuhiko

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulat Sci, Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan

[3] Tohoku Univ, Sch Med, Dept Pathol, Sendai, Miyagi 980, Japan

[4] Tokai Univ, Sch Med, Dept Pathol, Kanagawa 2591100, Japan

[5] Tohoku Univ, Sch Med, Dept Surg, Sendai, Miyagi 980, Japan

[6] Yamagata Univ, Sch Med, Dept Gastroenterol & Gen Surg Course Organ Funct, Yamagata 990, Japan

[7] Univ Tokyo, Fac Med, Dept Nephrol & Endocrinol, Tokyo 113, Japan

[8] Tokyo Womens Med Univ, Dept Endocrine Surg, Tokyo, Japan

[9] Takatsu Gen Hosp, Dept Med, Kawasaki, Kanagawa, Japan

[10] Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Div Endocrinol & Metab, Kyoto, Japan

[11] Kyoto Univ, Dept Surg, Kyoto, Japan

[12] Natl Hosp Org, Med Ctr, Clin Res Inst, Kyoto, Japan

[13] Osaka Univ, Grad Sch Med, Dept Surg, Osaka, Japan

[14] Osaka Saiseikai Noe Hosp, Dept Surg, Osaka, Japan

[15] Tokyo Med & Dent Univ, Grad Sch, Dept Clin & Mol Endocrinol, Tokyo, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2007年 / 42卷 / 06期

关键词：

neuroendocrine tumor; endocrine pancreatic tumor; gastrointestinal carcinoid; nationwide survey;

D O I：

10.1007/s00535-007-2056-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background. We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETS) newly diagnosed in Japan from 2002 through 2004. Methods. Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results. Nonfunctioning tumors (NF-PET) constituted 47.7% of PETS. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETS was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions. The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.

引用

页码：497 / 500

页数：4

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