Neutrophils in tuberculosis-first line of defence or booster of disease and targets for host-directed therapy?

被引：69

作者：

Dallenga, Tobias ^{[1
,2
]}

Schaible, Ulrich E. ^{[1
,2
]}

机构：

[1] Res Ctr Borstel, Prior Program Infect, Cellular Microbiol, Pk Allee 1-40, D-23845 Borstel, Germany

[2] German Ctr Infect Res, Themat Translat Unit TB, Pk Allee 1-40, D-23845 Borstel, Germany

来源：

PATHOGENS AND DISEASE | 2016年 / 74卷 / 03期

关键词：

neutrophils; tuberculosis; Mycobacterium tuberculosis; polymorphonuclear cells; host-directed therapy; DRUG-RESISTANT TUBERCULOSIS; ANTIMICROBIAL PEPTIDE LL-37; POST PRIMARY TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS; SUPPRESSOR-CELLS; PULMONARY TUBERCULOSIS; HUMAN MACROPHAGES; INTRACELLULAR BACTERIA; INFECTED MACROPHAGES; ACTIVE TUBERCULOSIS;

D O I：

10.1093/femspd/ftw012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Necrotizing granulomas, exacerbating pathogenesis and neutrophil influx at the site of infection are hallmarks of active pulmonary tuberculosis (TB) in humans. The role of polymorphonuclear neutrophils (PMN) in host defence and TB pathogenesis has recently attracted broader interest. Association of infiltrating PMN, enhanced mycobacterial load and disease exacerbation in both, mice susceptible to experimental TB as well as in TB patients, link PMN to exacerbated pathology. Targeting PMN resulted in smaller lung lesions and reduced mycobacterial burden. Therefore, PMN-associated molecules represent interesting biomarkers to determine TB severity and treatment success. More importantly, PMN are putative targets for host-directed therapies (HDT) in TB. Due to the rise of multi-and extensively drug-resistant Mycobacterium tuberculosis isolates, HDT represent adjunct measures to support antibiotic treatment by ameliorating pathology and local host defences.

引用

页数：8

共 70 条

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