Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate

被引：22

作者：

Vemooij, Robbin R. ^{[1
,2
,3
]}

Joshi, Tanmaya ^{[1
]}

Shaili, Evyenia ^{[3
]}

Kubeil, Manja ^{[1
]}

Appadoo, Dominique R. T. ^{[4
]}

Izgorodina, Ekaterina I. ^{[1
]}

Graham, Bim ^{[5
]}

Sadler, Peter J. ^{[3
]}

Wood, Bayden R. ^{[1
,2
]}

Spiccia, Leone ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Melbourne, Vic 3800, Australia

[2] Monash Univ, Ctr Biospectroscopy, Melbourne, Vic 3800, Australia

[3] Univ Warwick, Dept Chem, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England

[4] Australian Synchrotron, 800 Blackburn Rd, Clayton, Vic 3168, Australia

[5] Monash Univ, Monash Inst Pharmaceut Sci, Melbourne, Vic 3052, Australia

来源：

INORGANIC CHEMISTRY | 2016年 / 55卷 / 12期

基金：

英国工程与自然科学研究理事会; 澳大利亚研究理事会;

关键词：

FAR-INFRARED SPECTRA; PLATINUM(IV) COMPLEXES; RUTHENIUM COMPLEXES; PYRIDINE; DNA; TOXICITY; CRYSTALLINE; FREQUENCIES; GENERATION; CISPLATIN;

D O I：

10.1021/acs.inorgchem.6b00476

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report a detailed study of a promising photo-activatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N-3)(2)(OH)(2)(py)(2)] (Cl; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for Cl and its precursors (trans[Pt(N-3)(2)(py)(2)] (C2) and trans-[PtCl2(py)(2)] (C3)). Distinct IR- and Raman-active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for Cl in the mid- and far-IR region, which will provide a basis for the better understanding of the interaction of Cl with biomolecules.

引用

页码：5983 / 5992

页数：10

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