New Technical Aspects Used in the Management of Desensitization to Antineoplastic Drugs

Purpose of Review This review will focus on the most recent technical developments in rapid drug desensitization to antineoplastic agents (chemotherapy and biologics). It is designed as an update for the initiated and not a review of fundamental concepts. Recent Findings The recent publication of several international guidelines on diagnosing and managing drug hypersensitivity reactions to chemotherapy and biologics is set to revolutionize this field for allergy specialists. These guidelines resulted from leading groups coming together and collaborating to facilitate that allergy departments worldwide could expand the scope of their care to include these patients in dire need of urgent and safe solutions. Summary The article summarizes critical new concepts and points of view in management/governance (including setting up rapid drug desensitization teams), precision medicine, classifications, risk management, in vitro techniques, drug challenge and delabeling, premedication, innovative protocols (e.g., single-bag), and personalized medicine. This critical review will make the reader aware of the benefits and challenges of each innovation while informing new research.