New Drugs for the Treatment of Tuberculosis

被引：34

作者：

Ignatius, Elisa H. ^{[1
]}

Dooley, Kelly E. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Dept Med, Sch Med, 1830 Bldg Room 450B,1830 East Monument St, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Ctr TB Res, 600 North Wolfe St,Osler 527, Baltimore, MD 21205 USA

来源：

CLINICS IN CHEST MEDICINE | 2019年 / 40卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Tuberculosis; Bedaquiline; Delamanid; Pretomanid; New drugs; Pharmacology; MULTIDRUG-RESISTANT TUBERCULOSIS; EARLY BACTERICIDAL ACTIVITY; MURINE MODEL; MYCOBACTERIUM-TUBERCULOSIS; NITROIMIDAZOPYRAN PA-824; ANTITUBERCULOSIS DRUG; BEDAQUILINE TMC207; IN-VITRO; POPULATION PHARMACOKINETICS; STERILIZING ACTIVITY;

D O I：

10.1016/j.ccm.2019.08.001

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Tuberculosis (TB) has now surpassed HIV as the leading infectious cause of death, and treatment success rates are declining. Multidrug-resistant TB, extensively drug-resistant TB, and even totally drug-resistant TB threaten to further destabilize disease control efforts. The second wave in TB drug development, which includes the diarylquinoline, bedaquiline, and the nitroimidazoles delamanid and pretomanid, may offer options for simpler, shorter, and potentially all-oral regimens to treat drug-resistant TB. The "third wave" of TB drug development includes numerous promising compounds, including less toxic versions of older drug classes and candidates with novel mechanisms of action.

引用

页码：811 / +

页数：18

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