Pd/Phosphoramidite Thioether Complex-Catalyzed Asymmetric N-Allylic Alkylation of Hydrazones with Allylic Acetates

被引：25

作者：

Lu, Bin ^{[1
]}

Feng, Bin ^{[1
]}

Ye, Hui ^{[1
,2
]}

Chen, Jia-Rong ^{[1
]}

Xiao, Wen-Jing ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticides & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China

[2] Huanggang Normal Univ, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 12期

关键词：

LIGANDS; DESIGN; ALLYLATION;

D O I：

10.1021/acs.orglett.8b01226

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient Pd/phosphoramidite thioether complex-catalyzed asymmetric N-allylic alkylation of hydrazones with allylic acetates has been developed for the first time. The reaction allows for the preparation of various valuable N-substituted hydrazones with generally good yields and excellent enantioselectivities. Minor structural modification of the ligand resulted in opposite enantiomers, enabling enantiodivergent synthesis of products by the same catalytic system.

引用

页码：3473 / 3476

页数：4

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