Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

被引：9
作者：
Chu, Ting-Ting [1 ]
Li, Qian-Qian [1 ]
Qiu, Tian [1 ]
Sun, Zhan-Yi [1 ]
Hu, Zhi-Wen [1 ]
Chen, Yong-Xiang [1 ]
Zhao, Yu-Fen [1 ]
Li, Yan-Mei [1 ,2 ]
机构：
[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
[2] Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
来源：
MOLECULAR BIOSYSTEMS | 2014年 / 10卷 / 12期
基金：
中国国家自然科学基金;
关键词：
PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE; INDUCED DEFECTS; MOUSE MODELS; DEGRADATION; COPPER; REDUCTION; STRATEGIES; MEMORY;
D O I：
10.1039/c4mb00508b
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial 'hydrolase' I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable 'hydrolase' I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.
引用
收藏
页码：3081 / 3085
页数：5
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