Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

被引：9

作者：

Chu, Ting-Ting ^{[1
]}

Li, Qian-Qian ^{[1
]}

Qiu, Tian ^{[1
]}

Sun, Zhan-Yi ^{[1
]}

Hu, Zhi-Wen ^{[1
]}

Chen, Yong-Xiang ^{[1
]}

Zhao, Yu-Fen ^{[1
]}

Li, Yan-Mei ^{[1
,2
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Beijing Inst Brain Disorders, Beijing 100069, Peoples R China

来源：

MOLECULAR BIOSYSTEMS | 2014年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE; INDUCED DEFECTS; MOUSE MODELS; DEGRADATION; COPPER; REDUCTION; STRATEGIES; MEMORY;

D O I：

10.1039/c4mb00508b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial 'hydrolase' I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable 'hydrolase' I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.

引用

收藏

页码：3081 / 3085

页数：5

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