Efflux Pump Inhibitors: A Strategy to Combat P-Glycoprotein and the NorA Multidrug Resistance Pump

被引：47

作者：

Zhang, Ling ^{[1
]}

Ma, Shutao ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 06期

基金：

中国国家自然科学基金;

关键词：

cancer; inhibitors; multidrug resistance; NorA pump; P-glycoprotein; VITAMIN-E TPGS; STAPHYLOCOCCUS-AUREUS; DRUG-RESISTANCE; 2,4,5-TRISUBSTITUTED IMIDAZOLES; ORAL BIOAVAILABILITY; NONTOXIC MODULATORS; REVERSAL AGENTS; LEUKEMIA-CELLS; IN-VITRO; PHASE-I;

D O I：

10.1002/cmdc.201000006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Multidrug resistance (MDR) is the cause of an ever-increasing number of problems in the treatment of cancers and bacterial infections. The active efflux of drugs contributes significantly to this phenomenon. This minireview summarizes recent advances in combating MDR, with particular emphasis on natural and synthetic efflux pump inhibitors of P-glycoprotein in resistant tumor cells and of the NorA MDR pump in Staphylococcus aureus.

引用

页码：811 / 822

页数：12

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