Percutaneous long bone cementoplasty of the limbs: experience with fifty-one non-surgical patients

被引:34
作者
Cazzato, Roberto Luigi [1 ,2 ]
Buy, Xavier [1 ]
Eker, Omer [1 ]
Fabre, Thierry [1 ]
Palussiere, Jean [1 ]
机构
[1] Inst Bergonie, Dept Radiol, F-33000 Bordeaux, France
[2] Univ Campus Biomed Roma, Dept Radiol & Diagnost Imaging, I-00128 Rome, Italy
关键词
Long bone; Metastasis; Percutaneous cementoplasty; Cement leakage; Pathological fracture; PATHOLOGICAL FRACTURES; SKELETAL MORBIDITY; METASTASES; VERTEBROPLASTY; DISEASE; CANCER; FEMOROPLASTY; MANAGEMENT; CEMENT; LUNG;
D O I
10.1007/s00330-014-3357-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To review our 10-year experience with percutaneous long bone cementoplasty (PLBC) in poor surgical patients. Fifty-one patients were included. Primary endpoints were pain and functional outcomes one month following PLBC. A secondary endpoint dealt with factors predicting cement leakage. Delayed adverse events and overall survival (OS) were also investigated. Sixty-six lesions were treated. Local pain relief at 1-month occurred in 59/66 lesions (89.4 %); pain improvement was significantly more common for lesions of the upper limb (p < 0.05). Limb functionality at one month improved in 46/64 lesions (71.8 %); lesions a parts per thousand currency signaEuro parts per thousand 3 cm showed better outcomes in terms of limb function (p < 0.05). Cement leakage was minor and asymptomatic in 26 cases (26/66, 39.4 %); in one case (1/66, 1.5 %) symptomatic minor amount of intra-articular cement leakage occurred. Factors predicting cement leakage were diaphyseal location of the lesions, cortical bone disruption and extra-bone tumour extension (p < 0.05). The most common delayed adverse event was fracture (6/66, 9.1 %). OS at 1-, 2- and 3-years was 61.2 %, 30.9 % and 23.0 %, respectively. For poor surgical candidates, at 1-month follow-up, PLBC proved to be safe and effective. If stress fracture occurs following PLBC, surgical external fixation is still an affordable therapeutic option. aEuro cent Percutaneous long bone cementoplasty may be proposed to poor surgical patients aEuro cent Pain palliation is more significant for lesions of the upper limb aEuro cent Limb function improves significantly for lesions sized a parts per thousand currency signaEuro parts per thousand 3 cm aEuro cent Fracture is the most common delayed adverse event (9 % of cases) aEuro cent If cement stress fracture occurs, surgical external fixation is still feasible.
引用
收藏
页码:3059 / 3068
页数:10
相关论文
共 31 条
[1]   Treatment of Extraspinal Painful Bone Metastases with Percutaneous Cementoplasty: A Prospective Study of 50 Patients [J].
Anselmetti, Giovanni Carlo ;
Manca, Antonio ;
Ortega, Cinzia ;
Grignani, Giovanni ;
DeBernardi, Felicino ;
Regge, Daniele .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2008, 31 (06) :1165-1173
[2]  
Anselmetti Giovanni Carlo, 2010, Semin Intervent Radiol, V27, P199, DOI 10.1055/s-0030-1253518
[3]   Cementoplasty in the management of painful extraspinal bone metastases: Our experience [J].
Basile A. ;
Giuliano G. ;
Scuderi V. ;
Motta S. ;
Crisafi R. ;
Coppolino F. ;
Mundo E. ;
Banna G. ;
Di Raimondo F. ;
Patti M.T. .
La radiologia medica, 2008, 113 (7) :1018-1028
[4]   Palliative radiotherapy trials for bone metastases: A systematic review [J].
Chow, Edward ;
Harris, Kristin ;
Fan, Grace ;
Tsao, May ;
Sze, Wai M. .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (11) :1423-1436
[5]   Clinical features of metastatic bone disease and risk of skeletal morbidity [J].
Coleman, Robert E. .
CLINICAL CANCER RESEARCH, 2006, 12 (20) :6243S-6249S
[6]   The strengthening effect of percutaneous vertebroplasty [J].
Dean, JR ;
Ison, KT ;
Gishen, P .
CLINICAL RADIOLOGY, 2000, 55 (06) :471-476
[7]   Temperature elevation caused by bone cement polymerization during vertebroplasty [J].
Deramond, H ;
Wright, NT ;
Belkoff, SM .
BONE, 1999, 25 (02) :17S-21S
[8]   Percutaneous Stabilization of Impending Pathological Fracture of the Proximal Femur [J].
Deschamps, Frederic ;
Farouil, Geoffroy ;
Hakime, Antoine ;
Teriitehau, Christophe ;
Barah, Ali ;
de Baere, Thierry .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2012, 35 (06) :1428-1432
[9]   Hip fracture after radiofrequency ablation therapy for bone tumors: two case reports [J].
Dierselhuis, Edwin F. ;
Jutte, Paul C. ;
van der Eerden, Pepijn J. M. ;
Suurmeijer, Albert J. H. ;
Bulstra, Sjoerd K. .
SKELETAL RADIOLOGY, 2010, 39 (11) :1139-1143
[10]  
DIJKSTRA S, 1994, EUR J SURG, V160, P535