Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats

被引：16

作者：

Attanayake, Anoja Priyadarshani ^{[1
]}

Jayatilaka, Kamani Ayoma Perera Wijewardana ^{[1
]}

Pathirana, Chitra ^{[1
]}

Mudduwa, Lakmini Kumari Boralugoda ^{[2
]}

机构：

[1] Univ Ruhuna, Fac Med, Dept Biochem, Galle 80000, Sri Lanka

[2] Univ Ruhuna, Fac Med, Dept Pathol, Galle 80000, Sri Lanka

来源：

JOURNAL OF DIABETES RESEARCH | 2016年 / 2016卷

关键词：

DENSITY-LIPOPROTEIN CHOLESTEROL; HEALTHY; SERUM;

D O I：

10.1155/2016/4513871

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gmelina arborea Roxb. (common name: Et-demata, Family: Verbenaceae) has been used traditionally in Sri Lanka as a remedy against diabetes mellitus. The objective of the present study was to evaluate antidiabetic mechanisms of the aqueous bark extract of G. arborea in streptozotocin induced (STZ) diabetic male Wistar rats. Aqueous bark extract of G. arborea (1.00 g/kg) and glibenclamide as the standard drug (0.50 mg/kg) were administered orally using a gavage to STZ diabetic rats (65 mg/kg, ip) for 30 days. The antidiabetic mechanisms of aqueous extract of G. arborea (1.00 g/kg) were determined at the end of the experiment. The fasting blood glucose concentration was significantly lowered and the serum insulin and C-peptide concentrations were increased by 57% and 39% in plant extract treated rats on day 30, respectively (P < 0.05). The histopathology and immunohistochemistry results of the plant extract treated group showed a regenerative effect on beta-cells of the pancreas in diabetic rats. In addition, serum lipid parameters were improved in G. arborea extract treated diabetic rats. The results revealed that the aqueous stem bark extract of G. arborea (1.00 g/kg) showed beneficial effects against diabetes mellitus through upregulating the beta-cell regeneration and biosynthesis of insulin in diabetic rats.

引用

页数：8

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